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Journal > Jurnal Kesehatan Reproduksi > FRAKSI ETANOL 96% BIJI KORO BENGUK (Mucuna pruriens L.) SEBAGAI PENINGKAT KUALITAS SPERMATOZOA MENCIT (Mus musculus)

 

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Jurnal Kesehatan Reproduksi
Vol 1, No 2 Apr (2011)
FRAKSI ETANOL 96% BIJI KORO BENGUK (Mucuna pruriens L.) SEBAGAI PENINGKAT KUALITAS SPERMATOZOA MENCIT (Mus musculus)
Winarni, Sri ( Fakultas Kesehatan Masyarakat Universitas Diponegoro)
Judiwati, Rina ( Fakultas Kedokteran Universitas Airlangga)
Prajogo, Bambang ( Fakultas Farmasi Universitas Airlangga)
Hayati, Alfiah ( Fakultas Sains dan Teknologi Universitas Airlangga)
Article Info   ABSTRACT
Published date:
04 Nov 2012
 
Background: The examination of sperm quality is the main priority for infertility diagnosis. Based on previous study with mice, active ingredient of Mucuna pruriens L. or koro benguk (Papilionaceae), the L-dopa, may affect the quality of spermatozoa.Objective: Research was to study the effect of 96% ethanol fraction Mucuna pruriens seed on spermatozoaquality of mice exposed to 2-Methoxy ethanol. L-dopa in 96% ethanol fraction of M. pruriens seed was 14.7%.Methode: This was an experimental study using complete randomized design. Subjects were BALB/C mice (Mus musculus). Five groups served as control, 3 groups received subcutaneos injection of 2-ME as muchas 100 mg/kg.bw/day for 12 days, followed with 96% ethanol fraction Mucuna pruriens seed starting from14 mg/kg.bw/day, 28 mg/kg.bw/day, and 56 mg/kg.bw/day for 51 days.Result: The 96% ethanol fraction of Mucuna pruriens seeds are significant increase motility (p<0,01) andthe percentage of normal spermatozoa morphology (p= 0,042).Conclusion: 96% ethanol fraction of Mucuna pruriens seeds are able to increase motility and the percentage of normal spermatozoa morphology in mice exposed to 2-ME. Keywords: Mucuna pruriens L., L-dopa, mouse spermatozoa
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