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Journal > Journal of Chemistry > ANALISIS 8-ISOPROSTAN DALAM URIN TIKUS JANTAN WISTAR SETELAH TERPAPAR ETANOL DAN ASAP ROKOK

 

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Journal of Chemistry
Vol. 8, No. 1 Januari 2014
ANALISIS 8-ISOPROSTAN DALAM URIN TIKUS JANTAN WISTAR SETELAH TERPAPAR ETANOL DAN ASAP ROKOK
Article Info   ABSTRACT
Published date:
16 Aug 2014
 
The 8-isoprostane compound can be used for a biomarker of oxidative stress  formed by lipid peroxidation in the form of arachidonic acid with free radical in the body. The purpose of this study was to analysis  urinary 8-isoprostane in male Wistar rats after sub-acute exposer to ethanol and cigarette smoke. Extraction method used was solid phase extraction and the analysis was conducted by TLC and spectrophotodensitometry. The results showed that the 8-isoprostane compound was not detected in the male Wistar rat’s urine as control rats and in those exposed to cigarette smoke. The average concentrations of 8-Isoprostane in the male Wistar rat’s urine exposed to ethanol and combination of ethanol-cigarette were 1.519 ± 1,386 and 2.063 ± 1,308 ppm respectively.
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