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Journal > Jurnal Kedokteran Yarsi > Ekspresi interleukin-2 dan interleukin-10 pada kanker serviks uteri dengan positif HPV

 

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Jurnal Kedokteran Yarsi
Vol 12, No 1 (2004): Jurnal Kedokteran Yarsi
Ekspresi interleukin-2 dan interleukin-10 pada kanker serviks uteri dengan positif HPV
Article Info   ABSTRACT
Published date:
11 Jan 2012
 
ABSTRACTNow the pathogenesis of cervical cancer is pointed to lzuman papilloma virus (HPV). The immunity against cancer many unknown. Interleukin-2 (IL-2) act as growth and differentiation factor for natural killer (NK) cells. Interleukine-10 (IL-10) is a unique because it can be press and stimulate the immune response. The objective of this experiment is to known the expression of IL-2 and IL-10 in cervical cancer with HPV positive. DNA was isolated from nineteen samplescervical cancer tissues frozen section. Diagnose related with HPV made by PCR method. Paraffin block of the tissues cervical cancer with HPV infection was cut in throughly cleaned cryotome and place in glass plate that covered with polyelysine.The imnzunohistocheinistry is done with monoclonal antibody anti IL-2 and IL-10 with TSA -indirect method. Seventeen samples diagnosed HPV positive. The Result of this experiment show that expression of IL-2 and IL-10 in cervicalcancer with HPV positive are in mild category (30-70%). The experiment that related with cervical cancer immunology is very suggested.KEYWORDS IL-2, IL-10, Cervical cancer, HPV
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