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Journal > Indonesian Journal of Cancer Chemoprevention > QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model

 

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Indonesian Journal of Cancer Chemoprevention
Vol 1, No 2 (2010)
QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model
Firdayani, . ( Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT))
Kusumaningrum, Susi ( Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT))
Setyo Utomo, Doddy Irawan ( Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT))
Wibowo, Agung Eru ( Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT))
Chaidir, . ( Center of Pharmaceutical and Medical Technology Agency on Assessment and Application of Technology (BPPT))
Article Info   ABSTRACT
Published date:
31 Jul 2012
 
Rocaglamide derivatives are the compounds which have featuring cyclopenta[b]tetra-hydrobenzofuran skeleton. Until now it includes more than 50 naturally occurring derivatives. They were chosen to be interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy due to their cytotoxic activities data against various cancer cells. A quantitative structure activity relationship (QSAR) studies were done to investigate physicochemical properties of molecule which  contribute to their activities. Series of rocaglamide derivatives have been used and analyzed using linear free energy regression Hansch model for their cytotoxic activities against MONO-MAC-6 leukemia cells, RAJI lymphoma cells and MEL-JUSO melanoma cells. Results showed that the best QSAR equations were revealed involving C Log P and CMR parameters with nonlinear regression relationships in cytotoxic activities of rocaglamide derivatives against cancer cells above.
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