Announcement
Starting on July 4, 2018 the Indonesian Publication Index (IPI) has been acquired by the Ministry of Research Technology and Higher Education (RISTEKDIKTI) called GARUDA Garba Rujukan Digital (http://garuda.ristekdikti.go.id)
For further information email to portalgaruda@gmail.com

Thank you
Logo IPI  
Journal > Indonesian Journal of Chemistry > SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF 7-HYDROXY-3,4-DIMETHOXYFLAVONE

 

Full Text PDF (261 kb)
Indonesian Journal of Chemistry
Vol 12, No 2 (2012)
SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF 7-HYDROXY-3,4-DIMETHOXYFLAVONE
Susanti VH, Elfi ( Department of Chemistry, PMIPA FKIP, Sebelas Maret University, Jl. Ir Sutami 36 A Surakarta 53126)
Matsjeh, Sabirin ( Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281)
Wahyuningsih, Tutik Dwi ( Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281)
Mustofa, Mustofa ( Faculty of Medicine, Universitas Gadjah Mada, Jl. Sekip Utara Yogyakarta 55281)
Redjeki, Tri ( Department of Chemistry, PMIPA FKIP, Sebelas Maret University, Jl. Ir Sutami 36 A, Surakarta 53126)
Article Info   ABSTRACT
Published date:
09 Mar 2012
 
Synthesis of flavones and their derivatives has attracted considerable attention due to their significant pharmaceutical effects. 7-hydroxy-3,4-dimethoxyflavone has been synthesized and its antioxidant activity has been investigated. Flavone was synthesized by oxidative cyclization of chalcone. 2,4-dihydroxy-3,4-dimethoxychalcone was prepared by Claisen-Schmidt condensation of 2,4-dihydroxyacetophenones with 3,4-dimethoxybenzaldehydes in the presence of aqueous solution of sodium hydroxide and ethanol at room temperature. Oxidative cyclization of 2,4-dihydroxy-3,4-dimethoxychalcone was done by using I2 catalyst in DMSO to form 7-hydroxy-3,4-dimethoxyflavone. The synthesized compounds were characterized by means of their UV-Vis, IR, 1H-NMR and 13C-NMR spectral data. The compound was tested for their antioxidant activities by DPPH method.
Copyrights © 2012