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Journal > Media Gizi Mikro Indonesia > Hubungan Defisiensi Selenium dengan Thyroid Stimulating Hormone (TSH), Triiodothyronin (T3), dan Free Thyroxine (Ft4) pada Anak Sekolah Dasar di Daerah Endemik GAKI

 

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Media Gizi Mikro Indonesia
Vol 6, No 2 (2015)
Hubungan Defisiensi Selenium dengan Thyroid Stimulating Hormone (TSH), Triiodothyronin (T3), dan Free Thyroxine (Ft4) pada Anak Sekolah Dasar di Daerah Endemik GAKI
Ihsan, Nur ( Balai Litbang GAKI)
Nurcahyani, Yusi Dwi ( Balai Litbang GAKI)
Article Info   ABSTRACT
Published date:
22 Jan 2016
 
HUBUNGAN DEFISIENSI SELENIUM DENGAN THYROID STIMULATING HORMONE (TSH), TRIIODOTHYRONIN (T3), DAN FREE THYROXINE (fT4) PADA ANAK SEKOLAH DASAR DI DAERAH ENDEMIK GAKI   Selenium Deficiencies Association with Thyroid Stimulating Hormone (TSH), Triiodothyronin (T3) and Free Thyroxine (fT4) Levels in Endemic IDD Areas Primary School Children ABSTRACT Background. Iodine and selenium are essential micronutrients in the formation of thyroid hormones. Selenium plays a role in the conversion of T4 to T3, that its deficiency can affect thyroid hormone metabolism and exacerbate iodine deficiency.This study aimed to determine the relationship between selenium status and thyroid hormone status of primary school children in the endemic iodine deficiency areas. Methods. This is a cross sectional design study conducted in Candiroto, Temanggung district. The subjects were 70 students of the fourth, fifth and sixth grade of three elementary schools which were randomly selected.The selenium concentration in the serum were determined using atomic absorption spectrophotometry while the TSH, fT4 and T3 were measured using enzyme linked immunosorbent assay (ELISA) method. The data were analysed using spearman correlation and linear regression. Result. It was found that selenium status on all subjects were below standard, with a median of 21.2 (13.7 to 30.1) ug/L.Thyroid status were in the normal range, with the fT4 median and TSH mean of 8.5 (4.5 to 15.3) mg/L and 3.6 (± 2.0) mIU/L respectively. T3 levels were in the category below normal on 92.9 percent subjects with median of 0.7 (0.4 to 1.9) nmol/L. Almost 90 percent of the subjects consumed substandard iodized salt (> 30 ppm). There is significant correlation between selenium levels with TSH levels (r = 0.384; p = 0.001), however there are no significant correlation between selenium with fT4 and T3. Increased in TSH levels can predict increase in selenium levels after considering other variables (R2= 0,133). Conclusion. In this study, selenium deficiency is positively associated with TSH, but not significantly associated with fT4 and T3. Keywords: free T4, IDD, selenium, schoolchildren, T3.   ABSTRAK Latar Belakang. Iodium dan selenium merupakan mikronutrien yang penting dalam pembentukan hormon tiroid. Selenium berperan dalam konversi T4 ke T3, sehingga defisiensi selenium dapat mempengaruhi metabolisme hormon tiroid dan memperberat GAKI. Penelitian ini bertujuan untuk mengetahui hubungan status selenium dan status hormon tiroid anak sekolah dasar di daerah endemik GAKI. Metode. Desain penelitian menggunakan rancangan cross sectional. Lokasi penelitian di Kecamatan Candiroto salah satu daerah endemik berat GAKI di Kabupaten Temanggung. Sebanyak 70 sampel serum darah diambil dari siswa kelas 4, 5, dan 6 pada 3 sekolah dasar yang dipilih secara acak. Kadar Selenium diukur dengan menggunakan metode atomic absorption spectrophotometry sedangkan kadar TSH, fT4, dan T3 diukur dengan menggunakan metode enzyme linked immunosorbent assay (ELISA). Analisis data menggunakan uji korelasi spearman dan regresi linier. Hasil. Hasil penelitian menunjukkan bahwa seluruhsubyek (100%) memiliki status selenium di bawah normal, dengan median 21.2 (13.7 – 30.1) μg/L. Status tiroid dalam kisaran normal, dengan median fT4 dan rerata TSH 8.5 (4.5-15.3) μg/L dan 3.6 (+ 2.0) mIU/L berturut turut, sedangkan 92.9 percent kadar T3 subyek dalam kategori di bawah normal, dengan median 0.7 (0.4-1.9) nmol/L. Sebagian besar subyek (90 %) mengkonsumsi garam yang tidak memenuhi syarat (< 30 ppm). Terdapat korelasi positif yang bermakna secara statistik antara kadar selenium dengan kadar TSH (r = 0.384; p = 0.001). Tidak terdapat korelasi antara kadar selenium dengan kadar fT4 dan T3. Analisis regresi linier selenium dengan TSH setelah memperhitungkan variabel luar menghasilkan hubungan yang signifikan antara selenium dengan TSH (R2 = 0.133). Kesimpulan. Pada penelitian ini defisiensi selenium berhubungan positif dengan TSH, tetapi tidak berhubungan signifikan dengan fT4 dan T3. Kata kunci: fT4, GAKI, selenium, anak sekolah dasar, T3.
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