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Journal > Jurnal Kefarmasian Indonesia > Formulasi Tablet Salut Selaput Katekin dari Ekstrak Gambir (Uncaria gambir Roxb.)

 

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Jurnal Kefarmasian Indonesia
VOLUME 5, NOMOR 2, AGUSTUS 2015
Formulasi Tablet Salut Selaput Katekin dari Ekstrak Gambir (Uncaria gambir Roxb.)
Kurniatri, Arifayu Addiena ( Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan)
Adelina, Rosa ( Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan)
Setyorini, Herni Asih ( Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan)
Sulistyowati, Indah ( Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan)
Article Info   ABSTRACT
Published date:
28 Aug 2015
 
Gambir extract contains a high content of catechin. Catechin has so many benefits, such as antioxidant, antimicrobial, and anti-atherosclerosis.Gambir are widely available in Indonesia, especially in West Sumatra, might be a sustainable source of catechin. Catechin is easily oxidized and hygroscopic. Film coating is used to protect catechin contained in a tablet from moisture and light. Study of  film-coated tablet of catechin has not been conducted before. This study aims to formulate film-coated tablet of catechin from gambir and evaluate its physical properties. Catechin was percolated from gambir extract using ethyl astetat. The ethyl acetate fraction of gambir extract contains 92,48±0,28% catechin. Tablets were compressed with direct compression method and coated with a polymer coating material. The physical properties of core tablet and film-coated tablet were evaluated toward weight uniformity, hardness, friability, and disintegration time. Friability testing was  conducted only on core tablet. The formulation produced tablets with uniform weight, 16,6 ±1,97 Kp hardness, and 4 minutes 15 seconds disintegration time. Weight uniformity and disintegration time of the tablet meet the requirements
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