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Journal > Jurnal Sains Medika > Aspirin as a Chemopreventive Agent for Cancer: a New Hope?


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Jurnal Sains Medika
Vol 6, No 2 (2015)
Aspirin as a Chemopreventive Agent for Cancer: a New Hope?
Miladiyah, Isnatin ( Pharmacology Department Medical Faculty of Islamic Indonesian University (FK UII) Yogyakarta Corresponden : Kaliurang Street Km 14,5 Sleman 55584 Yogyakarta Office : (0274) 898444 psw 2096)
Article Info   ABSTRACT
Published date:
04 Jan 2016
Introduction: inflammation has been shown to play a major role in the pathogenesis of cancer. Inflammatory process activates the immune system through pro-inflammatory mediators and subsequent triggers transformation into malignant cells. Some tumors or cancers has been associated with chronic infections, such as hepatitis B and C viruses (hepatocellular carcinoma), human papilloma virus (cervical cancer), Helicobacter pylori (gastric cancer and lymphoma), and prostatitis (prostate cancer). A considerable study have investigated the benefits of aspirin for the prevention and treatment of cancer or tumors. Objectives: This paper aims to describe the relationship between inflammation and cancer incidence, so that use of aspirin as ananti-inflammatory agent is a rational choice in the treatment and prevention of cancer. Conclusion: Aspirin potential for chemoprevention of varioustypes of cancer. Considering the high risk of side effects of aspirin, aspirin is not intended as a routine therapy to prevent the occurrence of cancer.
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