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Journal > Journal of Tropical Life Science > RELATIONSHIP BETWEEN CYSTEINE, INTERLEUKIN (IL)-2, AND INTERLEUKIN (IL)-10 IN CHILDREN WITH MARASMUS TYPE MALNUTRITION

 

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Journal of Tropical Life Science
Vol 6, No 1 (2016)
RELATIONSHIP BETWEEN CYSTEINE, INTERLEUKIN (IL)-2, AND INTERLEUKIN (IL)-10 IN CHILDREN WITH MARASMUS TYPE MALNUTRITION
Article Info   ABSTRACT
Published date:
04 Mar 2016
 
 AbstractBackground: Malnutrition is one of the health issue in developing countries. The most commonly found malnutritin is the marasmus type. Infection in marasmus patient is the main cause of morbidity and mortality in developing countries. In marasmus, there is a decrease of protein level such as cysteine which is one of the gluthatione forming component that plays an important role in immune system. In malnutrition, there is a distrubance of lymphocyte in form of down-regulation of type 1 cytokine (IL-2 and IFN- γ) and up-regulation of type 2 cytokine (IL-4 and IL-10). IL-2 is needed for the development of regulator T produced by thymus and for NK cell cytotoxixity which plays a role in infectio process, while IL-10 inhibits activation of lymphocyte T so the cellular immunity reaction ends. Several studies about the relationship between cysteine, IL-2, and IL-10 have been done in malnutrition patients, but there is no study focusing on patients with marasmus. Aims: To find out the relationship between cysteine, IL-2, and IL-10 in patients with marasmus type malnutrition. Methods: This study was an analytic observational study using cross sectional design consisting of 20 children with marasmus type malnutrition and 20 well nourished children treated in Saiful Anwar Hospital Malang. The cysteine, IL-2, and IL-10 level then measured using Elisa method. Normality and variant test was done. The Pearson correlation test was done to find out the relationship between cysteine and IL-2 level, cysteine and IL-10 level, and IL-2 and IL-10. Results: The level of cysteine and IL-2 level in children  with marasmus is significantly lower than control group, which was 1.616±1.039 vs 3.298±0.519 pg/ml;p=0.000 dan 12.38±4.94 vs 16.58±4.80 pg/ml;p=0.010, respectively. IL-10 in children with marasmus was significantly higher than control group (19.08±5.93 vs 10.46±3.90 pg/ml;p=0.000). The cysteine level was positively correlated to the IL-2 level (p=0.000; r=0.71), while the cysteine and IL-10, IL-2 and IL-10 was negatively correlated with  p=0.014; r= -0.53 and p=0.037; r= -0.46 in marasmus.Conclusion: There was a positive correlation between the cysteine and IL-2 level and negative correlation between IL-10 and IL-2 also IL-2 and IL-10 in children with marasmus.Keywords: Serum Cysteine Level, IL-2 Level, IL-10 Level, Marasmus Type Malnutrition 
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