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Journal > INDONESIAN JOURNAL OF PHARMACY > Identification of cubebin and epicubebin isolated from Piper cubeba L.f fruits with two D-NMR spectroscopy

 

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INDONESIAN JOURNAL OF PHARMACY
Vol 16 No 4, 2005
Identification of cubebin and epicubebin isolated from Piper cubeba L.f fruits with two D-NMR spectroscopy
., Wahyono ( Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Indonesia)
Wahyuono, S. ( Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Indonesia)
Mursyidi, A. ( Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Indonesia)
Timmerman, H. ( Division of Medicinal Chemistry, Department of Pharmacochemistry, VrijeUniversiteit, The Netherlands)
Verpoorte, R. ( Department of Pharmacognosy, Gorleaus Laboratory, Leiden University, The Netherlands)
Hakim, L. ( Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Indonesia)
Article Info   ABSTRACT
Published date:
01 Oct 2005
 
One of the isolated active compound of the tracheospasmolytic from kemukus fruits (Piper cubeba L.f) is cubebin. The problem occurred when cubebin (C20H20O6) mixed with its epimer because of the difficultly to identify the structure by 1D-NMR spectroscopy. Structure identification then was conducted by 2D-NMR spectroscopy, so the structure of cubebin and epicubebin can be clear identified.
Key words : Cubebin, epicubebin, identification, 2D-NMR
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