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Journal > Jurnal Bahan Alam Indonesia > EFEK MUTAGEN EKSTRAK ETANOL BUAH CABE JAWA (Piper retrofractum Vahl.)

 

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Jurnal Bahan Alam Indonesia
Vol 1, No 2 (2002)
EFEK MUTAGEN EKSTRAK ETANOL BUAH CABE JAWA (Piper retrofractum Vahl.)
Isnawati, Ani ( Puslitbang Farmasi dan Obat Tradisional, Balitbangkes)
Endreswari, Sri ( Puslitbang Farmasi dan Obat Tradisional, Balitbangkes)
Pudjiastuti, . ( Puslitbang Farmasi dan Obat Tradisional, Balitbangkes)
Murhandini, . ( Badan Pengawas Obat dan Makanan)
Article Info   ABSTRACT
Published date:
01 May 2012
 
Cabe  Jawa  (Piper  retrofractum  Vahl.)  fruit  has  been  used  as  jamu.  On  the  other  hand,  it  was reported that it could cause abortion in rats and contraction isolated organ test. Referring to this side  effect,  and  for  long  lasting  administration,  as  safety  evaluation  must  be  completed  to  the possibility  of  mutagenic  effect.  The  research,  had  been  done  using  50%  ethanol  extract  of  Cabe Jawa  with  Ames  method  base  on  back  mutagen  system,  using  5  strain  of  mutagen  experimented bacteria i.e.: Salmonella thypi TA 98, TA 100, TA 1535, TA 1537 and Escherichia coli WP2 uvrA with and without S-9 metabolic activator. Negative and positive controls to detect appear of “point of mutation” had been used. The result showed that there was no mutagenic effect of 50% ethanol extract of Cabe Jawa.
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