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Journal > Jurnal Bahan Alam Indonesia > PENGARUH SKOPOLETIN DARI BUAH MENGKUDU (Morinda citrifolia L.) TERHADAP JUMLAH IgE MENCIT JANTAN DENGAN HIPERSENSITIVITAS TIPE I (Effect of scopoletin from mengkudu fruit to the amount of IgE on white male mice with type I hypersensitivity)

 

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Jurnal Bahan Alam Indonesia
Vol 8, No 2 (2012)
PENGARUH SKOPOLETIN DARI BUAH MENGKUDU (Morinda citrifolia L.) TERHADAP JUMLAH IgE MENCIT JANTAN DENGAN HIPERSENSITIVITAS TIPE I (Effect of scopoletin from mengkudu fruit to the amount of IgE on white male mice with type I hypersensitivity)
Aldi, Yufri ( Fakultas Farmasi Unand Padang)
Nasrul, Ellyza ( Fakultas Kedokteran Unand Padang.)
Yanwirasti, . ( Fakultas Kedokteran Unand Padang.)
Handayani, Dian ( Fakultas Farmasi Unand Padang.)
Bakhtiar, Amri ( Fakultas Farmasi Unand Padang.)
Article Info   ABSTRACT
Published date:
20 Jan 2013
 
In vitro study on scopoletin isolated from fruit of Mengkudu (Morinda citrifolia L.) to the amount of Imunoglobulin Epsilon (IgE) on white male mice with type I of hypersensitivity has been done. Result showed that scopoletin on the dose of 1,3 and 10 mg/kgBW was able to decrease the amount of IgE (P<0,01). Decrease in serum IgE levels of mice with type I hypersensitivity scopoletin by administering a dose of 10 mg/kg bw able to lower IgE levels to the normal range (p<0.01) Keywords : Morinda citrifolia L., scopoletin, type I of hypersensitivity, Imunoglobulin Epsilon (IgE). Abstrak Telah dilakukan penelitian secara in vitro pengaruh skopoletin dari buah mengkudu (Morinda citrifolia L.) terhadap jumlah immunoglobulin epsilon (IgE) pada mencit jantan dengan hipersensitivitas tipe I. hasil penelitian menunjukan pemberian skopoletin pada dosis 1,3 dan 10 mg/kg bb dapat menurunkan jumlah IgE pada mencit dengan hipersensitivitas tipe I  dengan pemberian skopoletin dosis 10 mg/kg bb mampu menurunkan kadar IgE sampai batas normal (p<0,01). Kata kunci :  mengkudu, skopoletin, hipersensitivitas tipe I, immunoglobulin epsilon (IgE).  
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