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Journal > Buletin Penelitian Sistem Kesehatan > PENGARUH POLIVINILPIROLIDON K-30 TERHADAP PENINGKATAN LAJU DISOLUSI ANDROGRAFOLIDA DENGAN SISTEM DISPERSI SOLIDA

 

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Buletin Penelitian Sistem Kesehatan
Vol 4, No 1 Jun (2001)
PENGARUH POLIVINILPIROLIDON K-30 TERHADAP PENINGKATAN LAJU DISOLUSI ANDROGRAFOLIDA DENGAN SISTEM DISPERSI SOLIDA
Suharmiati, Suharmiati ( Pusat Penelitian dan Pengembangan Pelayanan dan Teknologi Kesehatan)
Dyatmiko, Wahjo ( Fakultas Farmasi, Universitas Airlangga)
Ifansyah, Noor ( Fakultas Farmasi, Universitas Airlangga)
Article Info   ABSTRACT
Published date:
12 Nov 2012
 
Andrographolide is the main constituent of Andrographis paniculata Ness which was poorly soluble in water. As diterpenoid lactone andrographolide has many biological activity, some of them ara immunostimulant, antimalaria, hepatoprotector and anti mutagenic. The objectives of this study were to find out influence of polyvinylpirrolidon (PVP) K-30 to increase dissolution rate of andrographolide by solid dispersion in water and dissolution media pH 8,0. In this research andrographolide were divided in 6 groups that are physical mixture and solid dispersion by ratio 1:3; 1:5 and 1:9. Result of these study showed that the X-ray difraction patterns of physical mixture have crystal intensity as same as andrographolide crystal. But solid dispersion showed lower intensity. The solid dispersion system increase dissolution rate of andrographolide isolate. Increasing of dissolution rate a function of the ratio of drug to PVP used. Studies of dissolution rate have shown that coprecipitate of andrographolide-PVP K-30 (1:9) is better combination than 1:5 and 1:3.   Keywords: andrographolide, PVP K-30, solid dispersion and dissolution rate
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