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Journal > Jurnal Tumbuhan Obat Indonesia > POTENCY OF KEPEL (STELECHOCARPUS BURAHOL) AS CYCLOOXIGENASE-2 INHIBITOR

 

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Jurnal Tumbuhan Obat Indonesia
Vol 3, No 2 Des (2010)
POTENCY OF KEPEL (STELECHOCARPUS BURAHOL) AS CYCLOOXIGENASE-2 INHIBITOR
Batubara, Irmanida ( Biopharmaca Research Center, Bogor Agricultural University)
Darusman, Latifah K ( Biopharmaca Research Center, Bogor Agricultural University)
Djauhari, Edy ( Biopharmaca Research Center, Bogor Agricultural University)
Mitsunaga, Tohru ( Faculty of Applied Biological Science, Gifu University, Japan)
Article Info   ABSTRACT
Published date:
07 Feb 2013
 
Kepel (Stelechocatpus burabol (Blume) Hook & Thornson), one of fruit tree originally found in Indonesia, reported has anti-gout activity. In order to give more scientific data on anti-gout activity, we screened the cyclooxygenase 2 (COX-2) inhibitor activities of leaves and fruits extracts of Kepel. Kepel was collected from Karang Anyar, Nusa Kambangan, and Cilacap, Central Java, and also from Yogyakarta, Indonesia. Kepelleaves were extraeted with methanol and fractionated with ethyl acetate and water, while the fruits were extraeted with hexane and the residue was extraeted with ethyl acetic and water. The results showed that water extracts and methanol extracts of Kepelleaves and water extraet of Kepel fruits gave inhibitory activities about 51%. The fruits hexane and ethyl acetate extracts of Kepelleaves had only about 20% inhibitory activity. Keywords: Stelechocarpus burabol, Cyclooxygenase-z inhibitor
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