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Journal > Insisiva Dental Journal > THE EFFECTIVENESS OF TOFU LIQUID WASTE AS A NATURAL PHYTOESTROGEN FOR MANDIBULAR BONE OF OVARIECTOMIZED RATS

 

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Insisiva Dental Journal
Vol 1, No 1 (2012)
THE EFFECTIVENESS OF TOFU LIQUID WASTE AS A NATURAL PHYTOESTROGEN FOR MANDIBULAR BONE OF OVARIECTOMIZED RATS
Article Info   ABSTRACT
Published date:
20 Sep 2012
 
Background  :  Estrogen is a steroid compound that has many benefits for  the bodys physiology. Hypoestrogenic women could have periodontitis in their mouth. Hormone replacement therapy (HRT) is a therapy  that  used to reduce  the  disturbance caused by estrogen deficiency.  However, HRT has many side effects.  Theoretical study shows that isoflavones  in tofu liquid waste has an element of a steroid compound. The purpose of this study was to prove the effectiveness of isoflavones in the tofu liquid waste by examining the microscopic structure, estrogen receptor expression and MDA levels in rat mandibular bone post-ovariectomy. This research method use a true experimental laboratory with randomized post test control group design.  Methode:  Twenty-four female wistar rats were divided randomly into six groups, consisted  of a group of normal  rat  that  does’nt ovariectomized (C1), 4 weeks ovariectomized rats (C2), 8 weeks ovariectomized rats (C3) but no tofu liquid waste was given, and 8 weeks ovariectomized rats that given tofu liquid waste at the end of the 4th  week of ovariectomy with three different doses (C4 = 1.2, C5 = 6; C6 = 12 ml / kg). Histopathological slide  used to see the changes resulted in a number of osteoclasts, osteocytes, periodontal ligament width, alveolar bone height, the amount of estrogen receptor expression and MDA levels.  Result:  The results of statistical tests  show that  there is a difference in the rats between six different groups (ANOVA, p <0.05) and there is a close relationship between  the dose of the tofu liquid waste  with all parameter. Condlusion: The conclusion  of this study is tofu  liquid waste  could  improve the microscopic structure, estrogen receptor expression and MDA levels in rat mandibular bone post-ovariectomy.  Keywords: Menopause, Periodontitis, Isoflavones, Tofu Liquid Waste 
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